INSOM
Indian Society for OrthoMolecular Medicine

Research 

 

Interested in learning more about Orthomolecular Health?


Orthomolecular Health is a scientifically-based approach to healing and caring for the body. It employs the use of vitamins and nutrients in the form of diet and supplements to create a biochemical balance in the body. Below are many avenues to learn more about orthomolecular health:


Website resources: visit  Orthomolecular Health to read information about vitamin and mineral supplements and how they can help prevent and treat many of today’s conditions and illnesses.

 

Other resources:  www.orthomed.org  www.orthomolecular.org


Listen to podcasts of Orthomolecular experts speaking about the benefits of following the OM therapy:


Podcast 1: Introduction to Orthomolecular Medicine
Podcast 2: Orthomolecular Medicine and Multiple Sclerosis

Podcast 3: Orthomolecular Medicine and Schizophrenia

 



Web Resources  from  RIORDAN Clinic


Cancer Research - RECNAC



The RECNAC project was started in 1989 with the stated goal, contingent upon attaining set funding goals, to discover why cancer develops in humans and to devise methods for treating and preventing it without damaging normal tissue. All this within a ten year period! At the time it seemed absurd for a small institute such as ours to set such lofty goals when decades of cancer research, by thousands of brilliant scientists, at a host of prestigious institutions spending billions of dollars, had failed to find the elusive cure.


Video: (00:48)   Introduction to the RECNAC project by Hugh Riordan, M.D.

However, we had reasons to aim high. First, by setting our sights on the ultimate goal of a cure, we would be less likely to fall into the common practice of settling for lesser goals (to be published, to be respected in our profession, to earn NIH research grants, to achieve tenure, etc.) that might limit our progress. Second, by setting a finite time period for doing research, we would have an incentive to concentrate on areas that would lead to clinical applications. Finally, because of the Center’s nutrition based approach to medicine, the RECNAC project would be concentrating its research on areas that have been neglected by mainstream science.

The funding goals were not achieved, though the project was generously supported. However, we were able to undertake a variety of ambitious projects, and were extremely productive for an institute of our size. Eleven years after the start of the RECNAC project, we are proud to state our accomplishments: achievements that we feel offer new options and hope to cancer patients.


Ten Major RECNAC Accomplishments Relevant to Cancer Patients


1. Through the publication of papers, lectures, sponsorship of seminars and conferences and the establishment of interactive websites, we seek to spread knowledge of how cancers grow, alternative treatment possibilities and the importance of measurable, optimal nutrition for the prevention of cancer.

Video: (12:26)   Discussion on Cancer Prevention by James Jackson, Ph.D.

2. Demonstrated that vitamin C is toxic to tumor cells at concentrations that are achievable with high dose intravenous infusions.

3. Further demonstrated that when vitamin C is combined with lipoic acid, the dose required for tumor-cell killing decreases.

4. Demonstrated that vitamin C can be administered intravenously at sustained doses of at least 50g/day for 8 weeks without causing renal complications or significant alterations in blood counts or chemistry profiles.

5. Obtained evidence that vitamin C supplementation improves some parameters of immune cell functioning.

6. Successfully improved the condition of several cancer patients through the use of intravenous vitamin C, or combination of intravenous vitamin C with other antioxidants and immune stimulating agents.

Video: (14:48)   Overview of Vitamin C Therapy by Joseph Casciari, Ph.D.

7. Developed and tested a non-toxic extract from a locally grown plant that is capable of halting new blood vessel growth and inhibiting tumor growth.

8. Developed a method for producing an immune stimulant from bacterial culture that exhibits significant anti-tumor activity.

Video: (10:52)   Review of natural, non-toxic, anti cancer agents by Xiaolong Meng, M.D.

9. Developed a method by which a patient's white blood cells can be used to produce an autologous cytokine cocktail, and developed a protocol for administering this cocktail as a biological response modifier for cancer patients.

10. Gained the ability to grow dendritic cells and train them with tumor antigens obtained from the patient or produced cheaply in the laboratory. These antigen trained dendritic cells can be infused into patients to boost tumor-specific immune responses.

Video: (06:28)   Intro to Immunotherapy Research by Neil Riordan, PA-C, Ph.D.

Interest among the medical profession about high-dose intravenous Vitamin C is steadily growing. Reports come from around the world of doctors who have seen the benefits of high-dose intravenous Vitamin C. In our efforts, we hope to reduce the usual forty-year lag time between discovery and wide spread use of a new therapeutic modality.

Those that have and continue to benefit from holistic approaches including intravenous Vitamin C are true pioneers. Either because of or in spite of the treatment developed here and prescribed here and elsewhere, using methods that are not toxic to normal cells, they have eliminated any evidence of a variety of cancers, including adenocarcinoma of the breast, ductal carcinoma of the breast, lymphoma, bladder cancer and metastatic renal cancer.

Ongoing Clinical Applications of RECNAC Research

1. A clinical trial for the treatment of metastatic renal cancer using vitamin C in combination with lipoic acid and the natural immune supplements Immunopower and BioPro is in progress at the Center.

2. The Center is in the process of patenting a natural plant extract, and soon hopes to make more information on this extract, and perhaps the extract itself, available to co-learners.

3. The immunotherapy and anti-angiogenesis technologies developed at RECNAC have been licensed to Aidan, Inc, which is making them available to cancer patients.

4. Through The Center's "Beat the Odds" program, co-learners are able to have their antioxidant levels checked to be sure they are getting sufficient amounts of chemopreventative antioxidants.

Important Facts/Ideas Uncovered by RECNAC Research

1. Cancer patients are not only deficient in vitamin C, but they seem to have a large tissue demand for the vitamin.

2. The anti-tumor effect of vitamin C in a three-dimensional in vitro tumor model is increased substantially when applied in combination with lipoic acid or vitamin K3.

3. Phagocytes and lymphocytes obtained from people who supplement regularly with vitamin C have more activity in tests than those obtained from people who do not supplement.

4. The growth of dendritic cells, the cytotoxicity of T-lymphocytes, and the production of cytokines by stimulated monocytes, can be affected by variables such as cell density, incubation time, and vitamin C supplementation.

5. The application of low frequency magnetic fields can improve the anti-cancer effects of vitamin C and improve the proliferation of stimulated lymphocytes.

6. Blood contains red blood cell "inclusion bodies" that are made of cell membrane materials. These may be indicators of health problems.

7. Slight variations in temperature and the presence of electric or magnetic fields can affect cell growth.

8. The composition of fatty acids in cancer cells differs from that in normal cells, suggesting that cancer might be controlled by adjusting fatty acid balance.

The Impact of RECNAC on Future work at The Biocommunications Research Institute

1. The Biocommunications Research Institute, using techniques developed during the RECNAC project, is intensifying efforts to learn how nutrients and nutrient supplementation affect immune cell functioning.

2. The Biocommunications Research Institute will continue to be at the forefront of vitamin C related research. Building on RECNAC project results, the Institute will launch investigations of tissue vitamin C utilization and the effects of vitamin C depletion and supplementation on vitamin C stores and on health.

3. The Biocommunications Research Institute will expand studies concerning how subtle energies affect cells and people.

4. Development and analysis of phytochemical remedies will continue using the expertise gained by the Biocommunications Research Institute during its efforts in the RECNAC project.

References

1. Case Study: High-Dose Intravenous Vitamin C in the Treatment of a Patient with Adenocarcinoma of the Kidney, Riordan, H. D., Jackson, J. A., and Schultz, M., Journal of Orthomolecular Medicine, 5: 5-7, 1990.

2. Improved Microplate Fluorometer Counting of Viable Tumor and Normal Cells, Riordan, H. D., Riordan N. H., Meng, X., Zhong, J., Jackson, J. A., Anticancer Research, 14: 927-932, 1994.

3. High Dose Intravenous Vitamin C and Long Time Survival of a Patient with Cancer of the Head of the Pancreas, Jackson, J. A., Riordan, H. D., Hunninghake, R. E., and Riordan, N. H., Journal of Orthomolecular Medicine., 10: 87-88, 1995.

4. Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent. Riordan, N. H., Riordan, H. D., Meng, X., Li, Y., and Jackson, J. A. , Medical Hypotheses, 44(3), 207-13. 1995.

5. High-dose Intravenous Vitamin C in the Treatment of a Patient with Renal Cell Carcinoma of the Kidney, Riordan, H. D., Jackson, J. A., Riordan, N. H., and Schultz, M., Journal of Orthomolecular Medicine, 13: 72-73, 1998.

6. Cytotoxicity of Ascorbate, Lipoic Acid, and Other Antioxidants in Hollow Fibre in Vitro Tumours, Casciari J, Riordan N, Schmidt T, Meng X, Jackson J, Riordan H, British Journal of Cancer, 2001, 84(11):1544-1550.

7. Effects of a High Molecular Mass Convolvulus Arvensis Extract on Tumor Growth and Angiogenesis, Meng X, Riordan N, Casciari J, Zhu Y, Zhong J, Gonzalez M, Miranda-Massari J, Riordan H, Puero Rico Health Sciences Journal, 2002, 21(4):323-328.

Patents

1. Riordan, N. H., Riordan, H. D., Therapeutic method for the treatment of cancer. U.S. Patent No. 5,639,787, 1997.

2. Casciari, J. J., Riordan, H. D., and Riordan, N. H., Treatment of cancer using lipoic acid in combination with ascorbic acid. Pending.

3. Meng, X., Riordan, H. D., Riordan, N. H., Casciari J. J., and Taylor, P. T., Immune stimulating bacterial cell wall extracts. (To be submitted in 2000).

4. Meng, X., Riordan, N. H., Riordan, H. D., High molecular weight extracts of convolvulus arvensis (field bindweed). Pending.

5. Mikirova, N., et al, Method for improving therapeutic effectiveness of Ascorbic Acid for cancer treatment by using electromagnetic field exposure. (To be submitted in 2000).

6. Riordan, N. H., et al., Pharmaceutical preparation of cytokine production from mononuclear cells.

Our Research has been made possible by generous contributions by many many individuals, corporations and foundations. Because we do not accept tax derived government monies, our research depends solely upon private funding. We are grateful for the support of our research by Bob and Marge Page, The Olive White Garvey Trust, members of the Garvey family, Frank Horton, Bob Marietta, Dave and Sue O'Malley, The Flossie West Trust and the more than 1,000 contributors who receive "Throwing a Rope."

Achievements

Achievements

Read about how the Research division at the Riordan Clinic has garnered national recognition through innovative approaches.


Vitamin C Research - IVC



"...it takes much more than logic and clear-cut demonstrations to overcome the inertia and dogma of established thought." — Irving Stone


Irving Stone was an early thinker and writer about vitamin C (its scientific name is ascorbic acid). He knew it would be an uphill battle to change the way the medical profession viewed vitamin C. While most doctors accept that scurvy is a vitamin C deficiency illness, few have made the rather humongous jump to seeing high dose intravenous vitamin C as a major player in the management of cancer.

There is actually a wide spectrum of medical uses for vitamin C. Evidence exists documenting it as the best antiviral agent now available ... IF used at the proper dose. Vitamin C can neutralize and eliminate a wide range of toxins. Vitamin C will enhance host resistance, greatly augmenting the immune system's ability to neutralize bacterial and fungal infections. Now the National Institutes of Health has published evidence demonstrating vitamin C's anti-cancer properties. With so many medical benefits, why do so few doctors know of them?

One explanation stems from ascorbic acid's designation as a "vitamin." Consider Dorland's Illustrated Medical Dictionary's definition of vitamin: A general term for a number of unrelated organic substances that occur in many foods in small amounts that are necessary in trace amounts for the normal metabolic functioning of the body. As a vitamin, only a minuscule 60 mg of ascorbic acid is needed to prevent the emergence of scurvy symptoms. As a medical treatment for cancer and life-threatening infections and toxic exposures, tens of thousands of milligrams of ascorbic acid must be administered, often by the intravenous (IV) as well as the oral route.

The Center's founder, Dr. Hugh Riordan, was a true scientist who believed in the power of scientific measurement over dogma. With the establishment of The Center in 1975, he routinely checked plasma vitamin C levels in chronically ill patients. He found these sick patients to be consistently low in their plasma C levels. Interestingly enough, the cancer patients he was seeing had VERY LOW vitamin C reserves. This matched scientific literature documenting low vitamin C levels in cancer patients. Cancer cells were actively taking up vitamin C in a way that depleted tissue reserves of C.

PET scans are commonly ordered by oncologists to evaluate their cancer patients for metastases (cancer spread to other organs). What is actually injected into the patient at the start of the scan is radioactive glucose. Cancer cells are anaerobic obligates, which means they depend upon glucose as their primary source of metabolic fuel. Cancer cells employ transport mechanisms called glucose transporters to actively pull in glucose.

In the vast majority of animals, vitamin C is synthesized from glucose in only four metabolic steps. Hence, the molecular shape of vitamin C is remarkably similar to glucose. (Figure 1) Cancer cells will actively transport vitamin C into themselves, possibly because they mistake it for glucose. Another plausible explanation is that they are using the vitamin C as an antioxidant. Regardless, the vitamin C accumulates in cancer cells.

Figure 1: The molecular shape of vitamin C is remarkably similar to glucose.

If large amounts of vitamin C are presented to cancer cells, large amounts will be absorbed. In these unusually large concentrations, the antioxidant vitamin C will start behaving as a pro-oxidant as it interacts with intracellular copper and iron. This chemical interaction produces small amounts of hydrogen peroxide.

Because cancer cells are relatively low in an intracellular anti-oxidant enzyme called catalase, the high dose vitamin C induction of peroxide will continue to build up until it eventually lyses the cancer cell from the inside out! This effectively makes high dose IVC a non-toxic chemotherapeutic agent that can be given in conjunction with conventional cancer treatments. Based on the work of several vitamin C pioneers before him, Dr. Riordan was able to prove that vitamin C was selectively toxic to cancer cells if given intravenously. This research was recently reproduced and published by Dr. Mark Levine at the National Institutes of Health.

As feared by many oncologists, small doses may actually help the cancer cells because small amounts of vitamin C may help the cancer cells arm themselves against the free-radical induced damage caused by chemotherapy and radiation. Only markedly higher doses of vitamin C will selectively build up as peroxide in the cancer cells to the point of acting in a manner similar to chemotherapy. These tumor-toxic dosages can only be obtained by intravenous administration.

Over a span of 15 years of vitamin C research, Dr. Riordan's RECNAC (cancer spelled backwards) research team generated 20 published papers on vitamin C and cancer. RECNAC even inspired its second cancer research institute, known as RECNAC II, at the University of Puerto Rico. This group recently published an excellent paper in Integrative Cancer Therapies, titled "Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later." RECNAC data has shown that vitamin C is toxic to tumor cells without sacrificing the performance of chemotherapy.

Intravenous vitamin C also does more than just kill cancer cells. It boosts immunity. It can stimulate collagen formation to help the body wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade other organs throughout the body. It induces apoptosis to help program cancer cells into dying early. It corrects the almost universal scurvy in cancer patients. Cancer patients are tired, listless, bruise easily, and have a poor appetite. They don't sleep well and have a low threshold for pain. This adds up to a very classic picture of scurvy that generally goes unrecognized by their conventional physicians.

When Center cancer patients receive IVC, they report that their pain level goes down, and that they are better able to tolerate their chemotherapy. They bounce back quicker since the IVC reduces the toxicity of the chemotherapy and radiation without compromising their cancer cell killing effects. IVC is complementary to oncologic care. IVC is not "either/or" - it's a good "both/and" proposition. IVC can help cancer patients withstand the effects of their traditional therapies, heal faster, be more resilient to infection, develop a better appetite, and remain more active overall. These things promote a better response to their cancer therapy.

IVC has been used for three decades here at The Center. There have been no serious complications, but there are a couple of potential complications that need to be screened for. Because vitamin C enhances iron absorption, iron overload must be ruled out. The high sodium load of IVC can create a fluid overload in a patient with congestive heart failure, renal insufficiency or failure. We also check our patients for G6PD deficiency (an enzyme used to maintain stability of the red blood cell membranes). Although many physicians worry that large doses of vitamin C may cause kidney stones, we have rarely seen the phenomenon, and several huge clinical trials in the medical literature refute this misconception.

To summarize, most organisms make their own vitamin C. When they are under stress, either by illness or injury, Mother Nature has provided them with a means to facilitate healing: they synthesize more ascorbic acid. As a result, they are in less pain, they remain active, they can sleep, and they have a better appetite: all functions which promote healing.

Dr. Riordan once said that here at The Center, we don't treat cancer... we treat people who happen to have cancer. IVC is a tool that allows our Center physicians to harness a healing mechanism that our human ancestors lost long ago: the ability to dramatically increase tissue levels of vitamin C. Research shows that the astonishingly high levels achievable only by IVC not only help fight the risk of infection and the pain of metastases, they actually aid in the defeat of the cancer cells themselves, through a very elegant mechanism that does no harm to healthy cells. It's a discovery that the medical world is only beginning to discover.



Nutrients Research - WCN Skin Study




WCN Skin Lotion

A harmful environment surrounds our skin: UV waves from the sun,1 air pollution, chemicals on clothing (bleach, dyes, detergents, and synthetic fabrics), and chemicals in make-up and in skin lotion.2 At certain levels, our cells have mechanisms to resist these harmful factors, but they need adequate cellular nutrients to execute normal functions.3-5

Whole cellular nutrients (WCN) are the complete substances needed by cells to execute their normal functions. Our experiments show that when cells are exposed to harmful factors, such as UV and chemotherapeutic agents (DTIC), WCN has a protective effect ― more cultured cells survived in the presence of WCN than without (Fig.1, 2). The results indicated that, although harmful factors exist in the environment, WCN makes cells stronger, enabling them to survive a harsh environment.

WCN skin lotion is made based on the above concepts. It contains more than 240 nutrients that can be absorbed slowly by the skin to nourish and protect skin cells. Therefore, WCN skin lotion is not just a moisturizer; it is a nutrient mixture, providing many substances that skin cells need. It is a kind of whole food for your skin cells.

Our experiment shows that WCN skin lotion is able to protect apple cells from UV oxidation. A sliced apple was divided into two areas (Fig.3). The left side was coated with WCN lotion. The right side was coated with commercial Olay lotion. The grooved area was uncoated. The apple was exposed to UV waves for 10 minutes (UV-A, 940 µW/cm2). The pictures were taken while being exposed to UV waves. UV oxidized cells are brown. The darker the color, the more oxidized the apple cells are. WCN lotion has better oxidation protection than Olay lotion. This experiment shows that WCN lotion can protect live cells from oxidation. To extend this logic, applying WCN lotion should protect skin from oxidation, too. Therefore, it may delay the aging of skin, especially the areas exposed to the outside environment.

Use: For individuals with very sensitive skin, test any new lotion on your forearm skin (palm side) first. If no allergic reaction appears after 24 hours, you can apply the lotion on other locations. Having multiple nutrients, WCN lotion will benefit your skin, especially the areas exposed to the sunshine. In winter and spring, apply WCN lotion all over the body and it will nourish dry skin. Areas with age spots, sunspots, calluses, acne, eczema, keratosis, melanoma, psoriasis, and other skin lesions may also benefit from this lotion. The areas with odor, such as feet and armpits, are also good places to apply this lotion. However, do not apply this lotion to the eye area or to broken skin. Stop use immediately if allergic reactions or side effects occur. Apply the lotion as many times as you want every day. The more you use it, the more nutrients your skin will absorb and the more benefits your skin will have, such as preventing sunburn, fading your age spots, and minimizing wrinkles.

WCN lotion is always made fresh. To maximize the benefits of this lotion, use it as quickly as possible. We recommend finishing it out in 2~3 weeks since some light, temperature, and oxygen sensitive nutrients (such as Vc) degrade in the lotion as time passes. However, this is not the case for many other nutrients such as minerals and amino acids. To prolong usage time up to 4~6 months, keep the lotion in the refrigerator since our tests show that low temperature slows the degradation. The chart on the right side (Fig.4) shows the Vitamin C decline curve in the WCN skin lotion: in room temperature, Vc in the lotion dropped close to the baseline within 3 weeks and maintained a relatively low level for a long time. On the other hand, the Vc in the lotion kept in the refrigerator had a much slower degradation. Once oxygen sensitive nutrients are degraded, the antioxidant capacity and the available nutrients in the lotion for skin absorption would not be in full scale. Therefore, we use small packaging and recommend finishing it out in 3 weeks.

Table 1: Effects of WCN skin lotion tested on 37 volunteers for one month. The effects are as reported by the volunteers who tested the lotion.

Positive Effects
Count Percent
Softer skin
11
30%
Smother skin
5
14%
Moist skin
7
19%
Lighten age spots
5
14%
Clear acne faster
1
3%
Soften calluses
1
3%
Faster insect bite healing
1
3%
Faster urticaria healing
1
3%
No Change
5
14%
 
 
 
Negative Effects
 
 
None
34
92%
Slight redness
1
3%
Slight stinging during application
1
3%
Slight itching during application
1
3%

Examples of using WCN skin lotion on aging spots: the following pictures were taken under a UV-A light. UV-A light shows a better contrast of age spots on skin. After 2-4 weeks of using WCN skin lotion, the age spots faded.

Age spots on 40-year-old volunteer

Age spots on 50-year-old volunteer

Age spots on 55-year-old

Age spots on 65-year-old skin

Examples of using the lotion on other skin lesions: A woman got burned in similar locations on each hand. She applied the WCN skin lotion on one hand only and the burned skin healed quickly in 3-4 days, while the other burn without the WCN skin lotion required several additional days to heal completely

Skin lesion.

References:

1. Juan Ramos, et al: UV dose determines key characteristics of nonmelanoma Skin Cancer. Cancer Epidemiol. Biomarkers Prev., Dec 2004; 13: 2006 - 2011.
2. P S Friedmann, et al: ABC of allergies: Allergy and the skin. IIContact and atopic eczema. BMJ, Apr 1998; 316: 1226.
3. Christopher Duggan, et al: Protective nutrients and functional foods for the gastrointestinal tract. Am. J. Clinical Nutrition, May 2002; 75: 789.
4. Simin Nikbin Meydani, et al: Nutrients as regulators of immune function: Introduction. The FASEB Journal. 2001;15:2555.
5. Ulrike Heinrich, et al: Supplementation with §-Carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J. Nutr., Jan 2003; 133: 98.




Chy-Sawel Treatment Centre

For many years there was no adequate provision for the severely mentally ill in Cornwall, UK, with the result that patients were institutionalised in various parts of the country, resulting in separation from their families both in time and distance. Chy-Sawel Treatment Centre was set up for those suffering from schizophrenias and other mental illnesses. By adopting an orthomolecular treatment approach, it is the first Centre of its type in the UK. Their treatment is based on the pioneering work of Dr.Abram Hoffer and Dr.Carl Pfeiffer, in Canada and America respectively, known as orthomolecular or nutritional medicine. Their aim is to help participants re-enter society with a programme that will include occupational and recreational therapies, social re-education, psychotherapy and a holistic approach through the orthomolecular method

Center for the Improvement of Human Functioning

For more than 20 years, The Center for the Improvement of Human Functioning has been helping people who are ailing learn how to improve their health, regain their vigor and improve their performance with alternative approaches to healing.The Bio-Center Laboratory provides diagnostic services for physicians throughout the country to help reveal biochemical impairments and monitor their correction. The Mabee research library has over 2,500 books, 1,500 audio tapes, 700 videos, and 150 journals and newsletters which are utilized by patients, staff, researchers, students, and the public. The RECNAC cancer research project goals are to discover how and why cancer develops in humans, how to prevent it, and how to treat this disease using means which are not toxic to normal cells. The Institute also gathers clinical data about the effectiveness of the treatment protocols used by its doctors.

The Linus Pauling Institute

The mission of the LPI at OSU is to determine the function and role of micronutrients, phytochemicals and microconstituents of food in maintaining human health and preventing and treating disease; and to advance the knowledge in areas which were of interest to Linus Pauling through research and education. The LPI continues the pioneering efforts of Linus Pauling in orthomolecular medicine, an area of medicine devoted to restoring the optimal concentrations and functions of the substances (e.g., vitamins) normally present in the human body. The research at the LPI is aimed at understanding the molecular mechanisms and physiological effects of nutritional factors, and exploring their utilization in health promotion through disease prevention and treatment.

DoctorYourself.com

This site is a comprehensive and rich source of information on orthomolecular medicine for doctors and patients. Andrew Saul is Contributing Editor for the Journal of Orthomolecular Medicine, and DoctorYourself.com is his personal website, which receives over 1.5 million visitors annually. The information on this site is presented in a way which helps the layperson to understand the concept of orthomolecular treatment, how it differs from conventional medicine and how they can assert their right to safe, effective therapies in a conventional medical world. Archived newsletters and a massive searchable archive of treatments for common diseases make DoctorYourself well worth a visit.

Friends of Complementary and Alternative Medicine (FACT)

A community of discerning consumers and qualified professionals with a vision: the creation of a repository of health information that is factual, accessible, credible and ethical. The information comes from different schools of medicine and from different cultures. These diverse resources will provide us with multiple healthcare options, and it will lead us to a healthier future. Learn how you can consult or contribute your knowledge and experience to this growing body of knowledge and participate in our community's exciting and innovative vision.

The Way Up

Priscilla Slagle, M.D. is in the private practice of Nutritional /Functional Medicine & Psychiatry in Palm Springs & Encino, California.She is the author of The Way Up site which contains a great deal of information on nutritional medicine. She has helped thousands overcome the effects of stress, low moods, depression, & a variety of chronic symptoms & diseases and is one of the foremost experts on the prevention & treatment of mental and physical conditions by the use of amino acids. Dr. Slagle evaluates & treats numerous illnesses from a holistic perspective and is the author of "The Way Up From Down," a book on natural treatments for depression.

Health-Heart.Org

This not-for-profit public interest site looks at the food and supplement side of the heart health. Created by Eddy Vos, this site offers a comprehensive archive of medical and nutritional research without any commercial funding and provides the basic orthomolecular information necessary to improve your cardiovascular health.

Dr. Cathcart's Homepage

A great many links to orthomolecular papers, sites and other information by a leading practitioner in the field

Medweb: Alternative Medicine

A major internet jumpsite to complementary and alternative medicine sites.

20/20 technologies health archive

A good collection of complementary medicine related links covering basic nutrition facts, vitamins and aternative cancer therapies

Orthoeurope

News about orthomolecular medicine in the Dutch language, updated every day.

Dr. Huggins Website for information on Mercury Amalgam Toxicity

Dr. Huggins website is devoted to providing information and education to the public about dental materials (such as mercury, dental amalgam, nickel, and root canals) and practices that may be connected to health issues. Hugnet also discusses some of the emerging techniques being utilized to ensure safer dentistry.

The Rosenthal Center Directory of Databases

The literature on clinical and scientific research into alternative medicine treatments is widely scattered, as is background information on alternative medicine systems and approaches. This database is a compilation of established sources in the USA, Europe and Asia. The listing is hyperlinked to existing Web sites where available, or to brief information on the resource, such as: how to obtain further details; type of literature covered; size of the holding or mode of access.

Health World Online

A large complementary medicine site which includes the Journal of Orthomolecular Medicine's archives as well as other journals, professional organizations, libraries, and bookstores.

Arbor Nutrition Guide

The worlds largest searchable database of internet nutrition resources. Contains journal listings, food and nutrient databases, education resources, alternative medicine information and many other items.

Cyberspace Telemedical Office

A medical site which offers everything from searchable medical libraries to medical yellow pages and physician consultations. A good starting point for health care consumers.

Alternative Medicine Homepage

This page is a jumpstation for sources of information on alternative, complementary, and integrative therapies for the public.

Reuters Health News

Reuters provides daily breaking news in the health and medical field .

Web Resources: Advocacy

Center for the Improvement of Human Functioning

For more than 20 years, The Center for the Improvement of Human Functioning has been helping people who are ailing learn how to improve their health, regain their vigor and improve their performance with alternative approaches to healing.The Bio-Center Laboratory provides diagnostic services for physicians throughout the country to help reveal biochemical impairments and monitor their correction. The Mabee research library has over 2,500 books, 1,500 audio tapes, 700 videos, and 150 journals and newsletters which are utilized by patients, staff, researchers, students, and the public. The RECNAC cancer research project goals are to discover how and why cancer develops in humans, how to prevent it, and how to treat this disease using means which are not toxic to normal cells. The Institute also gathers clinical data about the effectiveness of the treatment protocols used by its doctors.

Earth House

Earth House is a model residential treatment center for young adults suffering from major mental disorders such as Schizophrenia and Bipolar disorder.
Located in a rural community near Princeton, New Jersey, Earth House accommodates a maximum of 14 residents generally ranging in age from 18 to 40. The minimum stay is 3 months; the average length of stay is 8 months; the maximum stay is 2 years. Most residents have had multiple diagnoses and have been previously hospitalized, some for 10 years or more. Earth House combines a medical and an educational approach. Medicines and nutrients are prescribed by physicians. To complement medical treatment, the program requires a wholesome diet, daily exercise and the development of habits that will assist recovery and support continued good health. Because of the strong learning orientation, residents are referred to as students rather than patients.

Nutrition, Health and Heart Disease

This not-for-profit public interest page looks at the food and supplement side of the picture and has a great deal of relevant material for those interested in nutrition and its relationship to health and disease.  For those interested in orthomolecular treatments for prevention and treatment of heart disease, this site has much useful information and links.

Canadian Complementary Medical Association

The CCMA is a network of Canadian physicians, osteopaths, residents and medical students with a special interest or expertise in complementary medicine. Their aim is to bring together the best of both conventional and alternative medicine for the benefit of patients. To reach this goal, they encourage education of physicians and public, complementary medical research and support for doctors practising complementary medical therapies.

Internet Mental Health

Internet Mental Health is a free encyclopedia of mental health information designed by a Canadian psychiatrist, Dr. Phillip Long, and programmed by his colleague,Brian Chow. The concept of Internet Mental Health is to use the Internet to freely share the vast amount of information on mental health with the world.

Hoffer's Home Page-The Schizophrenias

Abram Hoffer's Home page provides information on the orthomolecular treatment of schizophrenia, along with several detailed case studies of persons with schizophrenia who recovered using orthomolecular therapy.

Center for Science in the Public Interest

The Center for Science in the Public Interest (CSPI) is a nonprofit education and advocacy organization that focuses on improving the safety and nutritional quality of our food supply and on reducing the carnage caused by alcoholic beverages. CSPI seeks to promote health through educating the public about nutrition and alcohol; it represents citizens' interests before legislative, regulatory, and judicial bodies; and it works to ensure that advances in science are used for the public's good. CSPI is supported by 800,000 member-subscribers to its Nutrition Action Healthletter and through foundation grants and sales of educational materials.

Mental Health Net

MHN is one of the largest, most comprehensive guides to mental health online, featuring over 6,000 individual resources. This site covers information on disorders such as depression, anxiety, panic attacks, chronic fatigue syndrome and substance abuse, to professional resources in psychology, psychiatry and social work, journals and self-help magazines.

Health Research Institute

Health Research Institute is a leading force in the research and treatment of biochemical imbalances. Dedicated to improved health, The Health Research Institute is a vital component of total health care. The HRI mission is to increase the individual's ability to lead a productive and rewarding life,with the focus on research, education and nutritional treatment of biochemical imbalances. The Health Research Institute is a not-for-profit, public charity based in Naperville, Illinois. Since 1989, HRI's Pfeiffer Treatment Center has provided outpatient clinical services for thousands of behavior-disordered children and adults. The Center involves a collaboration between biochemists, nutritionists, and medical doctors who specialize in the effects of biochemistry on behavior and mental health. William J. Walsh, Ph.D. and H. Ronald Isaacson, Ph.D., co-founders of HRI, are researchers with more than 50 years of combined experience, including 30 years at Argonne National Laboratory in Lemont, Illinois.

Carl C. Pfeiffer Institute

The Pfeiffer Treatment Center is a not-for-profit medical research and treatment facility in Warrenville, Illinois specializing in research and treatment of biochemical imbalances. Since the center opened in 1989, it has treated nearly 20,000 patients who suffer from behavior dysfunctions, depression, schizophrenia, bipolar disorder, autism, learning disorders, or anxiety by balancing body and brain chemistry. The Pfeiffer Treatment Center, the medical clinic of the Health Research Institute (HRI), is staffed by a team of physicians, practitioners, chemists, and other professionals who specialize in the effects of biochemistry on behavior, thought, and mood. The on-site HRI Pharmacy compounds nutrients hormones, and other biochemicals to reduce the number of pills in a prescription using customized methods and equipment. he individualized biochemical treatment that Pfeiffer provides, based on the fact that each person has unique biochemistry, is a result of extensive research and has proven effective for patients seeking our help. An outcome study of the Pfeiffer Treatment Center’s biochemical therapy published in the October 15, 2004 issue of the peer-reviewed journal Physiology & Behavior provides strong evidence of treatment efficacy in patients presenting with tantrums, destructive behavior, and assaultive behavior. One of the few centers in the world with this biochemical focus, the Pfeiffer Treatment Center has grown into a thriving clinic with patients from 70 countries. In addition, the Center evaluates patients in other states during its Outreach Clinics. HRI continues to study biochemical imbalances and treatment of behavior, learning, and mood disorders. HRI and the Pfeiffer Treatment Center are constantly breaking barriers and expanding the frontiers of medicine.

The Schacter Center

The Schachter Center's director, Michael B. Schachter, M.D., is a 1965 graduate of Columbia College of Physicians & Surgeons. He is Board certified in Psychiatry and Chelation Therapy and has more than 20 years experience in complementary medicine. The center's staff of more than 50 work together to evaluate and treat patients who have a wide variety of medical complaints as well as those who simply wish to optimize their health. Biochemical testing is available. Treatment programs emphasize lifestyle changes and address diet, exercise, nutritional supplements and stress management. For many patients, programs involving injectable vitamins, minerals, chelating agents and bio-oxidative substances play a major role in treatment. Conditions they treat include: Heart and blood vessel disorders, Cancer, Arthritis, Chronic Fatigue Syndrome, Allergies, Candidiasis, Glandular Disturbances, Neurological Conditions, Immune System Disorders, Gastrointestinal Disorders, Gynecological Disorders, Musculoskeletal Disorders, Pediatric Disorders and Psychiatric Disorders.


Tahoma Clinic

The Tahoma Clinic is one of the finest nutritional medical clinics in the world and run by Dr. Jonathan Wright and the Tahoma Clinic staff. This centre providing non-prescription drug, non-surgical means to improved health, a state of the art clinical laboratory and many other resources.


The Center for the Study of Autism

CSA is located in the Salem/Portland, Oregon area. The Center provides information about autism to parents and professionals, and conducts research on the efficacy of various therapeutic interventions. Most of the research is in collaboration with Bernard Rimland's Autism Research Institute in San Diego, California.


The Ortho Institute

Dr. Gert Schuitemaker's orthomolecular organization of the Netherlands offers clinics, seminars, and publishes an orthomolecular journal and yearbook.


The Hoffman Center for Holistic Medicine

The Hoffman Center in New York City combines orthodox medicine and complementary modalities such as acupuncture, nutrition and vitamin therapy, chelation therapy, herbal medicine, sports medicine and pain treatment, allergy testing & treatment, environmental medicine and natural care for women. An on site diagnostic lab facility also provides analysis for patients.


The Amsterdam Kliniek

The Amsterdam Kliniek in the Netherlands specializes in integrative medicine, which utilises healing methods aimed at fighting disease in a natural way and promoting health without incurring damaging side effects. When needed, conventional therapies are integrated as part of the treatment.


Johnson Holistix

Dr. Johnson's clinic in Saskatoon, Saskatchewan,Canada specializes in orthomolecular medicine; chelation therapy and Orthopaedic medicine.


Nutritional Healing

Blake Graham's nutrition website, where there is information about the work of Abram Hoffer, Carl Pfeiffer, and many other orthomolecular physicians:

Linus Pauling Institute

The Linus Pauling Institute (LPI) was established at Oregon State University (OSU) in August 1996 under an agreement reached between its antecedent organization, the Linus Pauling Institute of Science and Medicine, and OSU.The mission of the LPI at OSU is to determine the function and role of micronutrients, phytochemicals and microconstituents of food in maintaining human health and preventing and treating disease; and to advance the knowledge in areas which were of interest to Linus Pauling through research and education.


International Society for Molecular Nutrition and Therapy

Located at the Molecular Cardiology Laboratory, Philipps University of Marburg, in Germany, the objectives of ISMNT are to promote nutritional research at the molecular level with respect to health and disease; to organize scientific meetings in the area of molecular nutrition including: cancer; cardiovascular diseases; immune disorders; neurosciences; nutritional abnormalities; vitamins and trace elements

Centro de Actualización Médica", Buenos Aires, Argentina

An orthomulecular institute in Buenos Aires, Argentina directed by Albert Dardanelli, M.D.


Aging Research Centre (ARC)

The Aging Research Centre is dedicated to providing a service that allows researchers in this field to find information that is related to the study of the aging process. ARC also endevours to introduce this field to laymen who would like to know more about the research that is being conducted in this field.


American College for Advancement in Medicine

The American College for Advancement in Medicine (ACAM) is a non-profit alternative medicine society dedicated to educating physicians on the latest findings and emerging procedures in preventive/nutritional medicine. ACAM's goals are not only to improve physicians' skills, knowledge, and diagnostic procedures, but also to develop awareness in the public at large of alternative methods of medical treatment.


Bastyr University

Batstyr University was founded in 1978 to train naturopathic physicians with a scientific approach. Since then, degree programs in nutrition, acupuncture and Oriental medicine, and applied behavioral science have been added, expanding the mission to serve as an effective leader and a vital force in the improvement of the health and well-being of the human community.


AANP

The American Association of Naturopathic Physicians website offers resources and information regarding disease prevention and health restoration, as well as curricula for naturopathic medical schools, and links to other organizations that share our mission to transform the medical paradigm from disease management and managed costs to true health care.


The Cognitive Enhancement Research Institute (CERI)

This web site familiarize visitors with information on new smart-drug-and-nutrient treatments for Down’s syndrome, Alzheimer’s disease and Parkinson's disease as well as provides holistically oriented physician referral services.

 
The Dutch Orthomolecular Education Foundation

The Dutch Orthomolecular Education Foundation S.O.E. (Stichting Orthomoleculaire Educatie) was founded in 1987 with the objective of distributing the expert knowledge and the application possibilities of orthomolecular science by supplying information and advice. Ruud A. Nieuwenhuis RA, founder and director of the S.O.E. is widely known as the tireless advocate of the orthomolecular movement in the Netherlands.

Web Resources: Periodicals

The PUFA Newsletter

Townsend Letter for Doctors and Patients

Alternative Medicine Review

Latitudes

Medical herbalism

Nutrition Science News

Health-Heart.org

AscorbateWeb

The Nutrition Reporter

Gary Null Guide to Natural Living

Web Resources: Medline

Medline will direct you to information to help answer health questions. MedlinePlus brings together authoritative information from NLM, the National Institutes of Health (NIH), and other government agencies and health-related organizations. MedlinePlus also has extensive information about drugs, an illustrated medical encyclopedia, interactive patient tutorials, and latest health news.

National Library of Medicine Medline

Infotrieve

We can provide a listing of health care practitioners who are associated with our Journal of Orthomolecular Medicine. This is in no way a recommendation for these individuals- it is your responsibility to inquire as to their expertise in orthomolecular therapy.
Please e-mail us your name and mailing address and the state or province which you would like a listing for, and we will send you an information package by post.e-mail
centre@orthomed.org

Alcoholism

Atherosclerosis

Arthritis

Cancer

Dementia

Diabetes

Depression

High Blood Pressure

HIV

Schizophrenia

Wound Healing

 

 

 

 

Linus Pauling Institute


The recommendations below are meant for generally healthy individuals interested in optimum health and preventing chronic diseases such as cardiovascular diseases (heart disease and stroke), diabetes, cancer, and osteoporosis. More detailed information regarding deficiencies of and requirements for specific nutrients is available in the Linus Pauling Institute's Micronutrient Information Center.


Healthy Eating

  • Eat at least five servings (2½ cups) of fruits and vegetables daily, but don't include potatoes in your tally. In fact, the latest Dietary Guidelines for Americans recommend that a person who consumes 2,000 calories a day should aim for nine daily servings of fruits and vegetables (the equivalent of 2½ cups of vegetables and 2 cups of fruit). More on fruits and vegetables
  • To increase your omega-3 fatty acid intake, eat fish twice weekly and eat foods rich in alpha-linolenic acid, such as walnuts, flaxseeds, and flaxseed and canola oil. More on omega-3 fatty acids
  • Use oils rich in unsaturated fats, such as soy, corn, safflower, and olive oil.
  • Reduce your intake of saturated and hydrogenated (trans) fat, such as butter, cheese, animal fat, stick margarine, and vegetable shortening.
  • Reduce your intake of potatoes, white flour, and white rice by substituting whole grain products, such as whole wheat flour and pasta, whole grain breads and cereals, and brown rice. More on whole grains
  • Avoid foods and drinks that are high in sugar and low in nutrients, such as soft drinks, sugar-coated breakfast cereals, and candy.
  • Limit your intake of overcooked or charred meat, and eat meat or fish with ample portions of vegetables.

Healthy Lifestyle

  • Aim for a healthy weight. Becoming overweight (BMI of 25-29.5) or obese (BMI of 30 or more) increases the risk of many chronic diseases. Calculate your BMI. Having too much abdominal fat (waist circumference greater than 40 inches for men and greater than 35 inches for women) also increases disease risk. If you are at risk of obesity-associated diseases (see table), even a relatively small weight loss (10% of your current weight) can help lower your risk.
  • Accumulate a minimum of 30 minutes of moderate-intensity exercise most days of the week. Most people can realize additional health benefits by increasing the duration of moderate-intensity exercise to an average of 60 minutes daily or by engaging in more vigorous physical activity. Examples of activities and their intensity levels. To improve muscular strength and balance and minimize bone loss, include strength-building activities, such as weight lifting, at least twice a week.
  • If you smoke, make every effort to quit. Even if you have smoked many years, quitting will result in dramatically decreased risk of chronic diseases. Smoking cessation resources
  • Moderate alcohol consumption is associated with reduced risk of cardiovascular diseases, but increased risk of some cancers. If you drink alcohol, limit your consumption to one alcoholic drink per day for women and two for men. Avoid alcohol if you have a personal or family history of breast or colon cancer or alcoholism. More on alcohol

Supplements

  • Multivitamins:

    Take a multivitamin supplement with 100% of the Daily Value (DV) for most vitamins and essential minerals, keeping the following suggestions in mind: More on multivitamins
    • Iron: In general, men and postmenopausal women should take a multivitamin without iron. More on iron
    • Vitamin A: Look for a multivitamin containing no more than 2,500 IU of vitamin A, or, if unavailable, a multivitamin containing 5,000 IU of vitamin A, of which at least 50% comes from beta-carotene. More on vitamin A
  • Vitamin C:

    Aim for a daily intake of at least 400 mg. Multivitamins usually provide 60 mg of vitamin C, and five servings of fruits and vegetables about 200 mg. More on vitamin C
  • Vitamin D:

    The Linus Pauling Institute recommends that generally healthy adults take 2,000 IU (50 mcg) of supplemental vitamin D daily. Most multivitamins contain 400 IU of vitamin D, and single ingredient vitamin D supplements are available for additional supplementation. More on vitamin D
  • Vitamin E:

    Take an extra supplement of 200 IU of natural source alpha-tocopherol (d-alpha-tocopherol) daily with a meal. More on vitamin E
  • Calcium:

    No multivitamin supplement contains 100% of the DV for calcium. If your total daily calcium intake doesn't add up to 1,000 mg add an extra calcium supplement (with a meal) to make up the difference. More on calcium

* More on the difference between Dr. Linus Pauling's recommendation and the Linus Pauling Institute's recommendation for vitamin C intake

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